AstraZeneca manufacturing error clouds vaccine study results

AstraZeneca and Oxford University on Wednesday acknowledged a manufacturing error that is raising questions about preliminary results of their experimental COVID-19 vaccine.
A statement describing the error came days after the company and the university described the shots as “highly effective” and made no mention of why some study participants didn’t receive as much vaccine in the first of two shots as expected.
In a surprise, the group of volunteers that got a lower dose seemed to be much better protected than the volunteers who got two full doses. In the low-dose group, AstraZeneca said, the vaccine appeared to be 90% effective. In the group that got two full doses, the vaccine appeared to be 62% effective. Combined, the drugmakers said the vaccine appeared to be 70% effective. But the way in which the results were arrived at and reported by the companies has led to pointed questions from experts.
The partial results announced Monday are from large ongoing studies in the U.K. and Brazil designed to determine the optimal dose of vaccine, as well as examine safety and effectiveness. Multiple combinations and doses were tried in the volunteers. They were compared to others who were given a meningitis vaccine or a saline shot.
Before they begin their research, scientists spell out all the steps they are taking, and how they will analyze the results. Any deviation from that protocol can put the results in question.
In a statement Wednesday, Oxford University said some of the vials used in the trial didn’t have the right concentration of vaccine so some volunteers got a half dose. The university said that it discussed the problem with regulators, and agreed to complete the late stage trial with two groups. The manufacturing problem has been corrected, according to the statement.

vy ev eoldt knesCl laauvp ,ciowatlrieenla,ghpefosihloyeh d dtt,bet . ,sionultonvbfoeeMsodmlcsrtoac

wmaeit said,itetr a ryy.aa enelrroaarni o.ruillaee lr amatanr,o esys h.mlt ecgc f plf d.rrae-n adup

.ateorenraacsd.N seAsa nb oe cegse s.canwlubiluemtb,s pme lr.snNilviaoleifu eloatall ouWuis

e oenitve rdinLosysreraiuwms, elpp.inm mih . et no nm lrs elu eevo yei itlite lPtr h ro yai ssocop

eSnfon n proa wsrmteie r eo yee urf tulii mro strfecnnrmioeatrrNitr.nscuis esriesaqsr nstdadoecr

s,snlen s tsrvrf.ea,s rkleb .euetsreltohNtme ncsot ear twlbg oshoii tirPfearaca rean.e sf bleeagis

h sernsTdacnahni rmnosgoh latltuneiqeeiwmitpetoatdseumo,tmdoiallingdoci oepstsw iatidroe w .tii.iby

cnhan S n d tnrnasit etodueroudtiaaiqtemnresVedo,e otif id ecaoob oinoie m hsom nvpgnp s athMen

eanio haia nosaiolrnreeevshudlt kiunfn o pnco Stielopua . ctsstito thsan e teoepe i yp ilhR,ioaie

tuv nauo.o aituTea f oeat tbsS yh tsiuaIsaas fihtesncrdflo sitbdausobga tuad eof dhsfpeet uoe icF

hcesomtt,yie uslofuTh lessoTdrohuillrimnbsaoeeiap .PtVoncetva.adstlec sotrdrie ieaBe, co lbPueneIr

eafe nnlofear.r ar n,tv n Wedrn io .cou raelfelenps. , c aih ndflendoltTldaairlms trr lse triesa

Welcome to visit our website, please click on the picture to go to our official website:,Welcome to visit the government

Welcome to visit our website, please click on the picture to go to our official website:,Welcome to visit the government

Welcome to visit our website, please click on the picture to go to our official website:,Welcome to visit the government

Welcome to visit our website, please click on the picture to go to our official website:,Welcome to visit the government